Application of an Enzymatic Microreactor Coupled with Microdialysis for Continuous Monitoring of Subcutaneous Glucose in Rats
نویسندگان
چکیده
We present here an application of a newly-designed enzymatic microreactor (EMR) for continuous glucose monitoring in rats. The EMR was based on electrochemical detection and was coupled with a microdialysis probe which was inserted into the subcutaneous tissue of anesthetized rats. The performance of the EMR was evaluated by modulating blood glucose concentrations with intravenous injections of glucose or insulin, with saline as a control. Blood glucose (BG) was frequently measured as a reference value for comparison with the EMR. The difference between glucose values produced by BG sampling and EMR monitoring are also discussed.
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